Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor

2015576 citationsJournal Article

Authors

William D. Tap · Memorial Sloan Kettering Cancer Center

Zev A. Wainberg · University of California, Los Angeles

Stephen P. Anthony

Prabha N. Ibrahim

Chao Zhang

John H. Healey · Memorial Sloan Kettering Cancer Center

Bartosz Chmielowski · Los Angeles Medical Center

Arthur P. Staddon · University of Pennsylvania

Abstract

Treatment of tenosynovial giant-cell tumors with PLX3397 resulted in a prolonged regression in tumor volume in most patients. (Funded by Plexxikon; ClinicalTrials.gov number, NCT01004861.).

Topics & Keywords

Musculoskeletal synovial abnormalities and treatments Bone Tumor Diagnosis and Treatments Sarcoma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 373, Issue 5, pp. 428-437

DOI: 10.1056/nejmoa1411366

Field-Weighted Citation Impact: 34.90