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Troy Smith | Researchclopedia

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Troy Smith

American Institutes for Research

18

Works

1,053

Citations

10

h-index

10

i10-index

Research Topics

Advanced Breast Cancer Therapies Protein Tyrosine Phosphatases Protein Degradation and Inhibitors

Affiliations

American Institutes for Research2020–2020

Boston Biomedical Research Institute2019–2019

Novartis (China)2019–2019

Novartis (United States)2003–2019

Top Works

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

Julien P. N. Papillon,Katsumasa Nakajima,et al.

2018230 citations

Chromatin Remodeling and Cancer

Cancer Mechanisms and Therapy

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche,Michael Acker,et al.

2020210 citations

<i>N</i>-Hydroxy-3-phenyl-2-propenamides as Novel Inhibitors of Human Histone Deacetylase with in Vivo Antitumor Activity: Discovery of (2<i>E</i>)-<i>N</i>-Hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1<i>H</i>-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824)

Stacy Remiszewski,Lidia Sambucetti,et al.

2003129 citations

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

Michael D. Shultz,Atwood K. Cheung,et al.

2013122 citations

4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6

Young Shin Cho,Maria Borland,et al.

201091 citations

Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors

Jeffrey T. Bagdanoff,Zhouliang Chen,et al.

201980 citations

Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight

B. Barry Touré,J. Giraldes,et al.

201651 citations

Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1

Julian Levell,Thomas R. Caferro,et al.

201646 citations

Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors

Young Shin Cho,Hayley C. Angove,et al.

201246 citations