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Jodie Pang | Researchclopedia

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Jodie Pang

Shenyang Pharmaceutical University ORCID

110

Works

3,695

Citations

31

h-index

48

i10-index

Research Topics

PI3K/AKT/mTOR signaling in cancer Glioma Diagnosis and Treatment Advanced Breast Cancer Therapies

Affiliations

Shenyang Pharmaceutical University2025–2025

Délégation Paris 52016–2016

Chongqing Normal University2025–2025

Merck & Co., Inc., Rahway, NJ, USA (United States)2014–2014

Austrian Institute of Technology2016–2016

Top Works

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Adrian Folkes,Khatereh Ahmadi,et al.

2008741 citations

Chronic Lymphocytic Leukemia Research

Drug Transport and Resistance Mechanisms

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Aaron Boudreau,Hans E. Purkey,et al.

2016258 citations

GDC-0980 Is a Novel Class I PI3K/mTOR Kinase Inhibitor with Robust Activity in Cancer Models Driven by the PI3K Pathway

Jeffrey J. Wallin,Kyle A. Edgar,et al.

2011227 citations

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

Daniel P. Sutherlin,Linda Bao,et al.

2011215 citations

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1<i>H</i>-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-<i>d</i>][1,4]oxazepin-9-yl]-1<i>H</i>-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Chudi Ndubaku,Timothy P. Heffron,et al.

2013175 citations

Discovery of (Thienopyrimidin-2-yl)aminopyrimidines as Potent, Selective, and Orally Available Pan-PI3-Kinase and Dual Pan-PI3-Kinase/mTOR Inhibitors for the Treatment of Cancer

Daniel P. Sutherlin,Deepak Sampath,et al.

2010131 citations

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

Emily J. Hanan,Marie-Gabrielle Braun,et al.

2022125 citations

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

Timothy P. Heffron,Chudi Ndubaku,et al.

2016105 citations

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of ( <i>S</i> )-2-((2-(1-Isopropyl-1 <i>H</i> -1,2,4-triazol-5-yl)-5,6-dihydrobenzo[ <i>f</i> ]imidazo[1,2- <i>d</i> ][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326)

Timothy P. Heffron,Robert A. Heald,et al.

2016104 citations