The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine

2003455 citationsJournal Article

Authors

Abstract

[reaction: see text] Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.

Topics & Keywords

Catalytic Alkyne Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Organic Letters

Volume 5, Issue 23, pp. 4473-4475

DOI: 10.1021/ol035781y

Field-Weighted Citation Impact: 12.14