Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

2014226 citationsReviewgold Open Access

Authors

Elza C. de Bruin · University College London

Nicholas McGranahan · CRUK Lung Cancer Centre of Excellence

Abstract

The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.

Topics & Keywords

Cancer Genomics and Diagnostics Statistical Methods in Clinical Trials Lung Cancer Treatments and Mutations

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 15, Issue 8, pp. 453-453

DOI: 10.1186/s13059-014-0453-8

Field-Weighted Citation Impact: 10.87