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Elza C. de Bruin | Researchclopedia

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Elza C. de Bruin

AstraZeneca (United Kingdom)ORCID

173

Works

4,167

Citations

23

h-index

30

i10-index

Research Topics

PI3K/AKT/mTOR signaling in cancer Cancer Genomics and Diagnostics Lung Cancer Treatments and Mutations

Affiliations

AstraZeneca (United Kingdom)2017–2025

DuPont (United States)1993–1993

Memorial Sloan Kettering Cancer Center2014–2014

University of Nottingham2019–2019

Institute of Cancer Research2014–2014

Top Works

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

Elza C. de Bruin,Nicholas McGranahan,et al.

20141,155 citations

Advanced Breast Cancer Therapies

Renal cell carcinoma treatment

Clonal status of actionable driver events and the timing of mutational processes in cancer evolution

Nicholas McGranahan,Francesco Favero,et al.

2015707 citations

Capivasertib Plus Paclitaxel Versus Placebo Plus Paclitaxel As First-Line Therapy for Metastatic Triple-Negative Breast Cancer: The PAKT Trial

Peter Schmid,Jacinta Abraham,et al.

2019380 citations

Apoptosis and non-apoptotic deaths in cancer development and treatment response

Elza C. de Bruin,Jan Paul Medema

2008273 citations

Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

Crispin T. Hiley,Elza C. de Bruin,et al.

2014226 citations

Reduced <i>NF1</i> Expression Confers Resistance to EGFR Inhibition in Lung Cancer

Elza C. de Bruin,Catherine Cowell,et al.

2014208 citations

A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in <i>PIK3CA</i> -Mutated Breast and Gynecologic Cancers

Udai Banerji,Emma Dean,et al.

2017144 citations

Circulating Tumor DNA and Late Recurrence in High-Risk Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer

Marla Lipsyc-Sharf,Elza C. de Bruin,et al.

2022137 citations

Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution

Michal Kováč,Carolina Navas,et al.

2015121 citations