Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms

2013170 citationsJournal Articlebronze Open Access

Authors

Jason M. Duran · Fox Chase Cancer Center

Catherine A. Makarewich · Fox Chase Cancer Center

Thomas E. Sharp · Fox Chase Cancer Center

Timothy Starosta · Fox Chase Cancer Center

Fang Zhu · Fox Chase Cancer Center

Nicholas E. Hoffman · Fox Chase Cancer Center

Yumi Chiba ·

Abstract

CBSCs improve survival, cardiac function, and attenuate remodeling through the following 2 mechanisms: (1) secretion of proangiogenic factors that stimulate endogenous neovascularization, and (2) differentiation into functional adult myocytes and vascular cells.

Topics & Keywords

Tissue Engineering and Regenerative Medicine Mesenchymal stem cell research Electrospun Nanofibers in Biomedical Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 113, Issue 5, pp. 539-552

DOI: 10.1161/circresaha.113.301202

Field-Weighted Citation Impact: 19.16