Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation

2016212 citationsJournal Articlebronze Open Access

Authors

Xinyuan Li · Fox Chase Cancer Center

Pu Fang · Temple University

Yafeng Li · Temple University Health System

Yin‐Ming Kuo · The Centers

Andrew J. Andrews · Fox Chase Cancer Center

Gayani Nanayakkara · Fox Chase Cancer Center

Candice Johnson ·

Abstract

ATP synthesis-uncoupled, but proton leak-coupled, mtROS increase mediates LPC-induced EC activation during early atherosclerosis. These results indicate that mitochondrial antioxidants are promising therapies for vascular inflammation and cardiovascular diseases.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases Adipokines, Inflammation, and Metabolic Diseases Sphingolipid Metabolism and Signaling

UN Sustainable Development Goals

Life below water

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 36, Issue 6, pp. 1090-1100

DOI: 10.1161/atvbaha.115.306964

Field-Weighted Citation Impact: 10.57