Analysis of Ginsenosides in Ginseng Drugs Using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

Analysis of ginsenosides in five Ginseng drugs derived from Panax ginseng (white ginseng), P. quinquefolius, P. japonicus produced in Japan, P. notoginseng, and P. vietnamensis using Liquid Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (LC-FTICR-MS) was performed. Ginsenosides in the drugs were identified by the molecular formula obtained from high-resolution mass data and multiple stage MS/MS analysis. Twenty-six known ginsenosides were identified as the major constituents in the extracts of the Ginseng drugs. The five Ginseng drugs showed different reconstructed mass chromatographic profiles and were discriminated from each other.