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Potent and selective bivalent inhibitors of BET bromodomains

2016134 citationsJournal Articlebronze Open Access

Authors

Michael J. Waring · AstraZeneca (United Kingdom)

Huawei Chen · AstraZeneca (United States)

Alfred A. Rabow · AstraZeneca (United Kingdom)

Graeme E. Walker · AstraZeneca (United Kingdom)

Romel Bobby · AstraZeneca (United Kingdom)

Scott Boiko · AstraZeneca (United States)

Rob H. Bradbury

Topics & Keywords

Protein Degradation and Inhibitors Multiple Myeloma Research and Treatments Ubiquitin and proteasome pathways

Publication Details

Published in: Nature Chemical Biology

Volume 12, Issue 12, pp. 1097-1104

DOI: 10.1038/nchembio.2210

Field-Weighted Citation Impact: 8.64

Potent and selective bivalent inhibitors of BET bromodomains | Researchclopedia

· AstraZeneca (United Kingdom)

Rowena Callis · AstraZeneca (United Kingdom)

Edwin Clark · AstraZeneca (United States)

Ian L. Dale · AstraZeneca (United Kingdom)

Danette L. Daniels · Promega (United States)

Austin Dulak · AstraZeneca (United States)

Liz Flavell · AstraZeneca (United Kingdom)

Geoffrey A. Holdgate · AstraZeneca (United Kingdom)

Thomas A. Jowitt · Wellcome Centre for Cell-Matrix Research

Alexey Kikhney · European Molecular Biology Laboratory

M. McAlister · AstraZeneca (United Kingdom)

Jacqui Méndez · Promega (United States)

D. Ogg · AstraZeneca (United Kingdom)

Joe Patel · AstraZeneca (United States)

Philip Petteruti · AstraZeneca (United States)

Graeme R. Robb · AstraZeneca (United Kingdom)

Matthew B. Robers · Promega (United States)

Sakina Saif · AstraZeneca (United States)

Natalie Stratton · AstraZeneca (United Kingdom)

Dmitri I. Svergun · European Molecular Biology Laboratory

Wenxian Wang · AstraZeneca (United States)

David Whittaker · AstraZeneca (United Kingdom)

David M. Wilson · AstraZeneca (United Kingdom)

Yi Yao · AstraZeneca (United States)