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Alfred A. Rabow | Researchclopedia

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Alfred A. Rabow

53

Works

1,549

Citations

19

h-index

20

i10-index

Research Topics

Estrogen and related hormone effects Protein Degradation and Inhibitors Multiple Myeloma Research and Treatments

Affiliations

AstraZeneca (United Kingdom)2005–2022

Cornell University1996–1996

East Cheshire NHS Trust2016–2016

National Cancer Institute2002–2006

Newcastle University2013–2013

Top Works

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and <i>ESR1</i> -Mutant Breast Tumors in Preclinical Models

Hazel M. Weir,Robert H. Bradbury,et al.

2016174 citations

Prostate Cancer Treatment and Research

Computational Drug Discovery Methods

Optimization of a Novel Binding Motif to (<i>E</i>)-3-(3,5-Difluoro-4-((1<i>R</i>,3<i>R</i>)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1<i>H</i>-pyrido[3,4-<i>b</i>]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist

Chris De Savi,Robert H. Bradbury,et al.

2015159 citations

AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies

Garrett W. Rhyasen,Maureen M. Hattersley,et al.

2016154 citations

Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular Activities

Alfred A. Rabow,Robert H. Shoemaker,et al.

2002135 citations

Potent and selective bivalent inhibitors of BET bromodomains

Michael J. Waring,Huawei Chen,et al.

2016134 citations

Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery

Robert Shoemaker,Dominic A. Scudiero,et al.

200292 citations

Molecular classification of cancer: unsupervised self-organizing map analysis of gene expression microarray data.

David G. Covell,Anders Wallqvist,et al.

200388 citations

Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3<i>R</i>)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-<i>b</i>]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)

Robert H. Bradbury,Rowena Callis,et al.

201685 citations

AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function <i>In Vitro</i> and <i>In Vivo</i>

Sarah A. Loddick,Sarah J. Ross,et al.

201377 citations