Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984499 citationsJournal Articlehybrid Open Access

Authors

G L Chen · Johns Hopkins University

Yang Liu · Johns Hopkins University

Thomas C. Rowe · Johns Hopkins University

Brian Halligan · Johns Hopkins University

K M Tewey · Johns Hopkins University

Leroy F. Liu · Johns Hopkins University

Abstract

shown to cleave DNA indirectly through their specific effect on the stabilization of a cleavable complex formed between mammalian DNA topoisomerase I1 and DNA (Nelson, E.

Topics & Keywords

Cancer therapeutics and mechanisms Synthesis and bioactivity of alkaloids Bioactive Compounds and Antitumor Agents

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Journal of Biological Chemistry

Volume 259, Issue 21, pp. 13560-13566

DOI: 10.1016/s0021-9258(18)90729-5

Field-Weighted Citation Impact: 7.43