Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts

202410 citationsJournal Articlegreen Open Access

Authors

Elyse A. Olesinski · Harvard University

Karanpreet Singh Bhatia · National University of Singapore

Chuqi Wang · National University of Singapore

Marissa S. Pioso · Harvard University

Xiao Xian Lin · National University of Singapore

Ahmed M. Mamdouh · National University of Singapore

Shu Xuan Ng

Abstract

Acquired resistance to targeted therapy remains challenging in AML. We found that reduction in mitochondrial priming and common transcriptomic signatures was a conserved mechanism of acquired resistance across different drug classes in vivo. Drugs active in vivo can be identified even in the multidrug resistant state by DBP.

Topics & Keywords

Drug Transport and Resistance Mechanisms Cancer therapeutics and mechanisms Acute Myeloid Leukemia Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Blood Cancer Discovery

Volume 5, Issue 3, pp. 180-201

DOI: 10.1158/2643-3230.bcd-24-0001

Field-Weighted Citation Impact: 2.83