Combined <scp>GPR40</scp> and <scp>GPR119</scp> full agonism with K‐757 and K‐833 results in robust glucose lowering and modest weight loss in overweight/obese subjects with <scp>T2DM</scp>

20251 citationsJournal Article

Authors

Michael F. Crutchlow · Kallyope (United States)

Jiajun Liu · Kallyope (United States)

Martha Hernandez‐Illas · San Diego Miramar College

Harry Zhang · Kallyope (United States)

Anna Arreglado · Kallyope (United States)

Annemarie Vance · Kallyope (United States)

Donald Boisvert

Abstract

Co-agonism of GPR40 and GPR119 with K-757 and K-833 elicits rapid, robust and glucose-dependent glucose lowering and modest weight loss in patients with T2DM on stable metformin.

Topics & Keywords

Diabetes Treatment and Management Hyperglycemia and glycemic control in critically ill and hospitalized patients Metabolism, Diabetes, and Cancer

Publication Details

Published in: Diabetes Obesity and Metabolism

Volume 27, Issue 11, pp. 6264-6274

DOI: 10.1111/dom.70014

Field-Weighted Citation Impact: 1.37

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Combined <scp>GPR40</scp> and <scp>GPR119</scp> full agonism with K‐757 and K‐833 results in robust glucose lowering and modest weight loss in overweight/obese subjects with <scp>T2DM</scp>

Authors

Abstract

Topics & Keywords

Publication Details