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Abstracts

20260 citationsJournal Articlegold Open Access

Authors

MCL1 is an anti-apoptotic BCL2 family protein overexpressed in over 22 tumor types · Institute for In Vitro Sciences

where it contributes to poor prognosis and resistance to therapies. Although clinical trials with MCL1 inhibitors targeting its cytosolic BH3 domain showed initial promise by inducing BAX/BAK-dependent apoptosis · Institute for In Vitro Sciences

many of these trials were halted due to on-target cardiotoxicity. We have identified a novel interaction between MCL1 and the pro-apoptotic protein BOK via their transmembrane domains · Institute for In Vitro Sciences

providing an alternative target to overcome resistance. · Institute for In Vitro Sciences

Topics & Keywords

Academic Publishing and Open Access Single-cell and spatial transcriptomics Genetics, Bioinformatics, and Biomedical Research

Publication Details

Published in: FEBS Open Bio

Volume 16, Issue S1, pp. S16-S53

DOI: 10.1002/2211-5463.70205

Field-Weighted Citation Impact: 0.00

Abstracts | Researchclopedia