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Institute for In Vitro Sciences | Researchclopedia
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Institute for In Vitro Sciences
Gaithersburg, Maryland
nonprofit
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Pharmacogenetics and Drug Metabolism
3D Printing in Biomedical Research
Immunotoxicology and immune responses
Computational Drug Discovery Methods
Inhalation and Respiratory Drug Delivery
Drug Transport and Resistance Mechanisms
Contact Dermatitis and Allergies
Pesticide Exposure and Toxicity
Drug-Induced Hepatotoxicity and Protection
J. D. Ruiz Alvarez
EIA University
1,322 works
56,972 citations
h-index: 109
Abstracts
MCL1 is an anti-apoptotic BCL2 family protein overexpressed in over 22 tumor types
,
where it contributes to poor prognosis and resistance to therapies. Although clinical trials with MCL1 inhibitors targeting its cytosolic BH3 domain showed initial promise by inducing BAX/BAK-dependent apoptosis
,
et al.
2026
0 citations