Fungal immunomodulatory proteins skew macrophages towards a pro-inflammatory and tumour inhibitory phenotype

20260 citationsJournal Articlegold Open Access

Authors

Yusi Liu · Institute of Food Science and Technology

Paulina Krzysica · Wageningen University & Research

Zhen Li · Institute of Food Science and Technology

Harry J. Wichers · Wageningen University & Research

Shanna Bastiaan-Net · Wageningen University & Research

Tamara Hoppenbrouwers · Wageningen University & Research

Abstract

rFIP-nha inhibited tumour growth in two distinct ways, by targeting tumour cells directly and by directing macrophage polarization towards a tumour inhibitory phenotype. This dual bioactivity makes FIP-nha interesting as an additive support in cancer immunotherapy.

Topics & Keywords

Immune cells in cancer Cancer Research and Treatments Immune responses and vaccinations

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Cancer Immunology Immunotherapy

Volume 75, Issue 4

DOI: 10.1007/s00262-026-04376-1

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