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Alexandra Grassian | Researchclopedia

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Alexandra Grassian

Blueprint Medicines (United States)

72

Works

3,445

Citations

14

h-index

14

i10-index

Research Topics

Protein Degradation and Inhibitors Chronic Myeloid Leukemia Treatments Chronic Lymphocytic Leukemia Research

Affiliations

Boston University2012–2012

Harvard University2009–2012

Hadassah Medical Center2009–2009

Blueprint Medicines (United States)2020–2026

Epizyme (United States)2015–2018

Top Works

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Jason W. Locasale,Alexandra Grassian,et al.

20111,114 citations

Cancer, Hypoxia, and Metabolism

Chromatin Remodeling and Cancer

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Zachary T. Schafer,Alexandra Grassian,et al.

20091,040 citations

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Alexandra Grassian,Seth J. Parker,et al.

2014286 citations

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

Alexandra Grassian,Christian M. Metallo,et al.

2011187 citations

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: <i>In Vitro</i> and <i>In Vivo</i> Preclinical Models

Elayne Chan-Penebre,Kelli Armstrong,et al.

2017165 citations

Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)

Alexandra Grassian,Fallon Lin,et al.

2012139 citations

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

Alexandra Grassian,Seth J. Parker,et al.

201494 citations

Apoptotic Pathways in Tumor Progression and Therapy

Armelle Melet,Keli Song,et al.

200792 citations

Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma

Satoshi Kawano,Alexandra Grassian,et al.

201675 citations