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Emma Dean | Researchclopedia

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Emma Dean

AstraZeneca (United Kingdom)ORCID

284

Works

5,465

Citations

37

h-index

84

i10-index

Research Topics

PARP inhibition in cancer therapy DNA Repair Mechanisms Lung Cancer Treatments and Mutations

Affiliations

AstraZeneca (United Kingdom)2017–2025

National Health Service2006–2006

Cliniques Universitaires Saint-Luc2019–2019

University of Liverpool2006–2006

Sarah Cannon Research Institute2018–2018

Top Works

AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

Jacqueline H. L. Fok,Antonio Ramos‐Montoya,et al.

2019327 citations

Cancer Genomics and Diagnostics

Ovarian cancer diagnosis and treatment

AKT Inhibition in Solid Tumors With <i>AKT1</i> Mutations

David M. Hyman,Lillian M. Smyth,et al.

2017321 citations

Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

Dominic G. Rothwell,Mahmood Ayub,et al.

2019304 citations

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Gerald S. Falchook,Jeffrey R. Infante,et al.

2021259 citations

Tisotumab vedotin in patients with advanced or metastatic solid tumours (InnovaTV 201): a first-in-human, multicentre, phase 1–2 trial

Johann S. de Bono,Nicole Concin,et al.

2019223 citations

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells

Rebecca L. Lloyd,Paul W.G. Wijnhoven,et al.

2020183 citations

A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in <i>PIK3CA</i> -Mutated Breast and Gynecologic Cancers

Udai Banerji,Emma Dean,et al.

2017144 citations

A phase I, pharmacokinetic and pharmacodynamic study of GSK2256098, a focal adhesion kinase inhibitor, in patients with advanced solid tumors

Jean‐Charles Soria,Hui Gan,et al.

2016141 citations

Biomarkers of apoptosis

Timothy H. Ward,Jeffrey L. Cummings,et al.

2008135 citations