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Martin Citron | Researchclopedia

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Martin Citron

UCB Pharma (Belgium)ORCID

123

Works

26,060

Citations

56

h-index

80

i10-index

Research Topics

Alzheimer's disease research and treatments Computational Drug Discovery Methods Cholinesterase and Neurodegenerative Diseases

Affiliations

Brigham and Women's Hospital1992–1998

Roche (United States)1999–1999

Amgen (United States)1998–2012

Harvard University1992–1998

Eli Lilly (United States)2010–2013

Top Works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar,Brian D. Bennett,et al.

19993,803 citations

Drug Transport and Resistance Mechanisms

Parkinson's Disease Mechanisms and Treatments

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner,Christopher B. Eckman,et al.

19962,587 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Martin Citron,Tilman Oltersdorf,et al.

19921,746 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

Martin Citron,David Westaway,et al.

19971,264 citations

Alzheimer's disease: strategies for disease modification

20101,061 citations

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo,Brad Bolon,et al.

2001992 citations

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Li-Bang Yang,Kristina Lindholm,et al.

2003724 citations

α-Synuclein Fibrillogenesis Is Nucleation-dependent

Stephen Wood,Jette Wypych,et al.

1999710 citations

Both Familial Parkinson's Disease Mutations Accelerate α-Synuclein Aggregation

Linda O. Narhi,Stephen Wood,et al.

1999706 citations