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Julian Downward | Researchclopedia

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Julian Downward

The Francis Crick Institute ORCID

665

Works

62,643

Citations

114

h-index

285

i10-index

Research Topics

Protein Kinase Regulation and GTPase Signaling PI3K/AKT/mTOR signaling in cancer Lung Cancer Treatments and Mutations

Affiliations

Semmelweis University2007–2007

Ontario Institute for Cancer Research1986–1986

Google (United States)1996–1996

The Honourable Society of Lincoln's Inn1984–2015

National Institutes of Health2003–2003

Top Works

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Marco Gerlinger,Andrew J. Rowan,et al.

20127,707 citations

Cancer Immunotherapy and Biomarkers

Cancer-related Molecular Pathways

Targeting RAS signalling pathways in cancer therapy

Julian Downward

20033,221 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

A Ullrich,Lisa M. Coussens,et al.

19842,767 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

Julian Downward,Yosef Yarden,et al.

19842,530 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

Pablo Rodriguez‐Viciana,Patricia H. Warne,et al.

19941,929 citations

Mechanisms and consequences of activation of protein kinase B/Akt

Julian Downward

19981,306 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

Andrea Kauffmann-Zeh,Pablo Rodriguez‐Viciana,et al.

19971,158 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

László Buday,Julian Downward

19931,079 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

Pablo Rodriguez‐Viciana,Patricia H. Warne,et al.

19971,067 citations