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Isaac Hoffman | Researchclopedia

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Isaac Hoffman

State Street (United States)ORCID

47

Works

592

Citations

15

h-index

19

i10-index

Research Topics

Crystallization and Solubility Studies X-ray Diffraction in Crystallography Cytokine Signaling Pathways and Interactions

Affiliations

State Street (United States)2024–2026

ActiveSite Pharmaceuticals (United States)2009–2009

Takeda (United States)2011–2020

Nanospectra Biosciences (United States)2024–2026

New York University1978–1978

Top Works

Discovery of [<i>cis</i>-3-({(5<i>R</i>)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1<i>H</i>-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5<i>H</i>)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist

Mitsunori Kono,Atsuko Ochida,et al.

201862 citations

Fibroblast Growth Factor Research

Protein Kinase Regulation and GTPase Signaling

Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

Tomohiro Okawa,Yoshio Aramaki,et al.

201760 citations

Discovery of TAK-659 an orally available investigational inhibitor of Spleen Tyrosine Kinase (SYK)

Betty Lam,Yasuyoshi Arikawa,et al.

201660 citations

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode

Jun Fujimoto,Osamu Kurasawa,et al.

201939 citations

Discovery of Clinical Candidate <i>N</i>-((1<i>S</i>)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-<i>b</i>]pyrazine-4(1<i>H</i>)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders

Satoshi Mikami,Shinji Nakamura,et al.

201737 citations

Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors

Leslie W. Tari,Isaac Hoffman,et al.

200637 citations

Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis

Giovanni Cianchetta,Terry R. Stouch,et al.

201034 citations

Assessment of the Target Engagement and d-Serine Biomarker Profiles of the d-Amino Acid Oxidase Inhibitors Sodium Benzoate and PGM030756

Eimear Howley,Michael Bestwick,et al.

201729 citations

A model for decoding resistance in precision oncology: acquired resistance to FGFR inhibitors in cholangiocarcinoma

Love Goyal,Daniel DiToro,et al.

202428 citations