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R. Scott Obach | Researchclopedia

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R. Scott Obach

Pfizer (United States)ORCID

303

Works

24,184

Citations

83

h-index

198

i10-index

Research Topics

Pharmacogenetics and Drug Metabolism Computational Drug Discovery Methods Drug Transport and Resistance Mechanisms

Affiliations

Roche (Switzerland)2018–2018

Tufts University2003–2003

Biogen (United States)2018–2024

National Institute on Drug Abuse2019–2019

General Dynamics (United States)2007–2007

Top Works

An oral SARS-CoV-2 M <sup>pro</sup> inhibitor clinical candidate for the treatment of COVID-19

Dafydd R. Owen,Charlotte Allerton,et al.

20211,859 citations

Analytical Chemistry and Chromatography

Metabolomics and Mass Spectrometry Studies

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

19991,205 citations

THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE

Thorir D. Bjornsson,John T. Callaghan,et al.

2003784 citations

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data.

R. Scott Obach,James G. Baxter,et al.

1997638 citations

A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups

Amit S. Kalgutkar,Iain Gardner,et al.

2005615 citations

Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Deepak Dalvie,Amit S. Kalgutkar,et al.

2002513 citations

VALIDATED ASSAYS FOR HUMAN CYTOCHROME P450 ACTIVITIES

Robert L. Walsky,R. Scott Obach

2004502 citations

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach,Robert L. Walsky,et al.

2006454 citations

Managing the challenge of chemically reactive metabolites in drug development

B. Kevin Park,Alan R. Boobis,et al.

2011450 citations