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Alexander E. Perl | Researchclopedia

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Alexander E. Perl

University of Pennsylvania ORCID

412

Works

15,666

Citations

55

h-index

137

i10-index

Research Topics

Acute Myeloid Leukemia Research Chronic Myeloid Leukemia Treatments Chronic Lymphocytic Leukemia Research

Affiliations

Children's Hospital of Philadelphia2005–2005

Thomas Jefferson University2011–2011

Rensselaer Polytechnic Institute2021–2021

Hospital of the University of Pennsylvania2006–2024

AbbVie (United States)2021–2021

Top Works

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward,Jay Patel,et al.

20101,967 citations

Protein Degradation and Inhibitors

Myeloproliferative Neoplasms: Diagnosis and Treatment

Gilteritinib or Chemotherapy for Relapsed or Refractory <i>FLT3</i> -Mutated AML

Alexander E. Perl,Giovanni Martinelli,et al.

20191,194 citations

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Catherine C. Smith,Qi Wang,et al.

2012738 citations

Selective inhibition of FLT3 by gilteritinib in relapsed or refractory acute myeloid leukaemia: a multicentre, first-in-human, open-label, phase 1–2 study

Alexander E. Perl,Jessica K. Altman,et al.

2017486 citations

Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD acute myeloid leukaemia (QuANTUM-R): a multicentre, randomised, controlled, open-label, phase 3 trial

Jörge E. Cortes,Samer K. Khaled,et al.

2019471 citations

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

Lori S. Hart,John T. Cunningham,et al.

2012440 citations

Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia

Christine M. McMahon,Timothy T. Ferng,et al.

2019422 citations

Acute Myeloid Leukemia, Version 3.2019, NCCN Clinical Practice Guidelines in Oncology

Martin S. Tallman,Eunice S. Wang,et al.

2019420 citations

Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse

Mark J. Levis,Farhad Ravandi,et al.

2011397 citations