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Wayne J. Fairbrother | Researchclopedia

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Wayne J. Fairbrother

Gene Therapy Laboratory ORCID

263

Works

17,990

Citations

61

h-index

127

i10-index

Research Topics

Cell death mechanisms and regulation Protein Degradation and Inhibitors Ubiquitin and proteasome pathways

Affiliations

Scripps Research Institute1992–1992

Amgen (United States)2016–2016

National Institute of Occupational Health2008–2008

Genentech2010–2017

Purdue University West Lafayette1994–1994

Top Works

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers,Joel Johansson,et al.

20132,979 citations

Multiple Myeloma Research and Treatments

Monoclonal and Polyclonal Antibodies Research

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev,John W. Blankenship,et al.

20071,199 citations

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Avi Ashkenazi,Wayne J. Fairbrother,et al.

2017893 citations

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz,Saritha Kusam,et al.

2011809 citations

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Joel Johansson,Darren C. Phillips,et al.

2015536 citations

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

Eugene Varfolomeev,Tatiana Goncharov,et al.

2008535 citations

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

J D Leverson,H Zhang,et al.

2015427 citations

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessène,Peter E. Czabotar,et al.

2013370 citations

Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3

Xiaoqing Sun,Jianping Yin,et al.

2002366 citations