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Severin Lechner | Researchclopedia

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Severin Lechner

Austrian Research Institute for Artificial Intelligence ORCID

21

Works

408

Citations

9

h-index

9

i10-index

Research Topics

Histone Deacetylase Inhibitors Research Peptidase Inhibition and Analysis Protein Degradation and Inhibitors

Affiliations

Austrian Academy of Sciences2025–2025

Austrian Research Institute for Artificial Intelligence2026–2026

Bioanalytica (Switzerland)2025–2025

CeMM Research Center for Molecular Medicine2025–2025

Technical University of Munich2021–2025

Top Works

Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target

Severin Lechner,Martin Ian P. Malgapo,et al.

2022108 citations

Epigenetics and DNA Methylation

Ubiquitin and proteasome pathways

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Jana Zecha,Florian Bayer,et al.

2023100 citations

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Raphael R. Steimbach,Corey J. Herbst‐Gervasoni,et al.

202240 citations

Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics

Stephan Eckert,Nicola Berner,et al.

202434 citations

A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics

Johanna Tüshaus,Amirhossein Sakhteman,et al.

202331 citations

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Severin Lechner,Raphael R. Steimbach,et al.

202327 citations

Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics

Yun-Chien Chang,Christian Gnann,et al.

202418 citations

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Martin P. Schwalm,Johannes Dopfer,et al.

202415 citations

Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition

Carina Glas,Eli Naydenova,et al.

202213 citations