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Joanne C. McGrail | Researchclopedia

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Joanne C. McGrail

Manchester Academic Health Science Centre ORCID

30

Works

459

Citations

9

h-index

9

i10-index

Research Topics

Ovarian cancer diagnosis and treatment RNA modifications and cancer PARP inhibition in cancer therapy

Affiliations

Manchester Academic Health Science Centre2024–2026

University of Manchester2006–2026

St Mary's Hospital2025–2026

Cancer Research UK Manchester Institute2021–2026

Cancer Research UK Manchester Centre2020–2023

Top Works

Distinct transcriptional programs stratify ovarian cancer cell lines into the five major histological subtypes

Bethany M. Barnes,Louisa Nelson,et al.

2021127 citations

Cancer Genomics and Diagnostics

DNA Repair Mechanisms

The function of the NineTeen Complex (NTC) in regulating spliceosome conformations and fidelity during pre-mRNA splicing

Rebecca Hogg,Joanne C. McGrail,et al.

2010113 citations

The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing

Joanne C. McGrail,Amanda Krause,et al.

200942 citations

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

Camilla Coulson‐Gilmer,Robert D. Morgan,et al.

202138 citations

<i>TP53</i> loss initiates chromosomal instability in fallopian tube epithelial cells

Daniel Bronder,Anthony Tighe,et al.

202132 citations

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre‐mRNA splicing

Joanne C. McGrail,Elaine M Tatum,et al.

200625 citations

The U1, U2 and U5 snRNAs crosslink to the 5′ exon during yeast pre-mRNA splicing

Joanne C. McGrail,Raymond T. O’Keefe

200723 citations

Exploiting a living biobank to delineate mechanisms underlying disease-specific chromosome instability

Louisa Nelson,Bethany M. Barnes,et al.

202318 citations

Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors

Anya Golder,Louisa Nelson,et al.

202211 citations