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Joseph Schoepfer | Researchclopedia

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Joseph Schoepfer

Novartis (Switzerland)ORCID

86

Works

4,126

Citations

31

h-index

41

i10-index

Research Topics

Heat shock proteins research Chemical Synthesis and Analysis Protein Kinase Regulation and GTPase Signaling

Affiliations

Novartis (Switzerland)1996–2024

Howard Hughes Medical Institute1995–1995

Harvard University1995–1995

University of Basel2009–2009

Novartis (Germany)2011–2011

Top Works

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

Andrew A. Wylie,Joseph Schoepfer,et al.

2017583 citations

Computational Drug Discovery Methods

Chronic Myeloid Leukemia Treatments

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1

Joseph Schoepfer,Wolfgang Jahnke,et al.

2018436 citations

Structural basis for specificity of GRB2-SH2 revealed by a novel ligand binding mode

Joseph Rahuel,Brigitte Gay,et al.

1996238 citations

NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models

Michael Rugaard Jensen,Joseph Schoepfer,et al.

2008222 citations

Discovery of a Potent and Selective Protein Kinase CK2 Inhibitor by High-Throughput Docking

Eric Vangrevelinghe,Kaspar Zimmermann,et al.

2003215 citations

Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-<i>d</i>]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

Paul A. Brough,Xavier Barril,et al.

2009173 citations

Capmatinib (INC280) Is Active Against Models of Non–Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation

Sabrina Baltschukat,Barbara Schacher Engstler,et al.

2019173 citations

Inhibition of Cyclin-Dependent Kinase 4 (Cdk4) by Fascaplysin, a Marine Natural Product

Rajeev Soni,Lionel Muller,et al.

2000163 citations

Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)

Stefania Sarno,E. De Moliner,et al.

2003138 citations