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Pengda Liu | Researchclopedia

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Pengda Liu

University of North Carolina at Chapel Hill ORCID

140

Works

7,886

Citations

43

h-index

73

i10-index

Research Topics

Ubiquitin and proteasome pathways interferon and immune responses PI3K/AKT/mTOR signaling in cancer

Affiliations

University of North Carolina at Chapel Hill2017–2026

Beth Israel Deaconess Medical Center2011–2019

Harvard University2011–2019

Cancer Research Institute2015–2015

East Carolina University2010–2010

Top Works

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Le Yu,Jessica Wei,et al.

2021686 citations

Cancer-related Molecular Pathways

Protein Degradation and Inhibitors

Roles of F-box proteins in cancer

Zhiwei Wang,Pengda Liu,et al.

2014535 citations

CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1

Bartlomiej Bartkowiak,Pengda Liu,et al.

2010397 citations

PtdIns(3,4,5) <i>P</i> 3-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu,Wenjian Gan,et al.

2015375 citations

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Pengda Liu,Michael J. Begley,et al.

2014365 citations

Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Xiangpeng Dai,Wenjian Gan,et al.

2017333 citations

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Pengda Liu,Wenjian Gan,et al.

2013254 citations

mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

Daming Gao,Hiroyuki Inuzuka,et al.

2011247 citations

Cytosolic DNA sensing by cGAS: regulation, function, and human diseases

Le Yu,Pengda Liu

2021230 citations