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Rohitha Sriramaratnam | Researchclopedia

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Rohitha Sriramaratnam

Jnana Therapeutics (United States)ORCID

18

Works

7,460

Citations

8

h-index

8

i10-index

Research Topics

PI3K/AKT/mTOR signaling in cancer Click Chemistry and Applications Ubiquitin and proteasome pathways

Affiliations

Howard Hughes Medical Institute2013–2013

University of Basel2019–2024

Jnana Therapeutics (United States)2025–2026

Centrexion Therapeutics (United States)2024–2024

Harrison Medical Center2024–2024

Top Works

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang,Rohitha Sriramaratnam,et al.

20147,226 citations

Protein Degradation and Inhibitors

Advanced Breast Cancer Therapies

(<i>S</i>)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase

Denise Rageot,Thomas Bohnacker,et al.

201954 citations

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα

Chiara Borsari,Erhan Keleş,et al.

202253 citations

Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

Georg Petzold,Pablo Gaínza,et al.

202553 citations

4-(Difluoromethyl)-5-(4-((3<i>R</i>,5<i>S</i>)-3,5-dimethylmorpholino)-6-((<i>R</i>)-3-methylmorpholino)-1,3,5-triazin-2-yl)pyridin-2-amine (PQR626), a Potent, Orally Available, and Brain-Penetrant mTOR Inhibitor for the Treatment of Neurological Disorders

Chiara Borsari,Erhan Keleş,et al.

202022 citations

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition

Georg Petzold,Pablo Gaínza,et al.

202417 citations

Identification of PDE6D as a Molecular Target of Anecortave Acetate <i>via</i> a Methotrexate-Anchored Yeast Three-Hybrid Screen

Allan R. Shepard,Raymond E. Conrow,et al.

201316 citations

Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity

Hemant Varma,N. Gangadhar,et al.

201313 citations

Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling

Lukas Bissegger,Theodora A. Constantin,et al.

20247 citations