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John A. Flygare | Researchclopedia

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John A. Flygare

Merck & Co., Inc., Rahway, NJ, USA (United States)

98

Works

6,657

Citations

37

h-index

49

i10-index

Research Topics

HER2/EGFR in Cancer Research Cell death mechanisms and regulation Monoclonal and Polyclonal Antibodies Research

Affiliations

Northwestern University1991–1991

University of Iowa1997–1997

Merck & Co., Inc., Rahway, NJ, USA (United States)2018–2024

Amgen (United States)2006–2017

Genentech2010–2013

Top Works

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Eugene Varfolomeev,John W. Blankenship,et al.

20071,199 citations

Cancer Treatment and Pharmacology

Ubiquitin and proteasome pathways

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar,Thomas H. Pillow,et al.

2015820 citations

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

Helena Mancebo,Gary Lee,et al.

1997540 citations

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessène,Peter E. Czabotar,et al.

2013370 citations

Discovery of a Potent and Selective BCL-X <sub>L</sub> Inhibitor with <i>in Vivo</i> Activity

Zhi‐Fu Tao,Lisa Hasvold,et al.

2014328 citations

Discovery of a Potent Small-Molecule Antagonist of Inhibitor of Apoptosis (IAP) Proteins and Clinical Candidate for the Treatment of Cancer (GDC-0152)

John A. Flygare,Maureen H. Beresini,et al.

2012247 citations

Antibody‐Drug Conjugates for the Treatment of Cancer

John A. Flygare,Thomas H. Pillow,et al.

2012229 citations

Targeting LGR5 <sup>+</sup> cells with an antibody-drug conjugate for the treatment of colon cancer

Melissa R. Junttila,Weiguang Mao,et al.

2015180 citations

Design, Synthesis, and Biological Activity of a Potent Smac Mimetic That Sensitizes Cancer Cells to Apoptosis by Antagonizing IAPs

Kerry Zobel,Lan Wang,et al.

2006174 citations