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Gerdien E. de Kloe | Researchclopedia

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Gerdien E. de Kloe

Vrije Universiteit Amsterdam

14

Works

522

Citations

10

h-index

10

i10-index

Research Topics

Receptor Mechanisms and Signaling Nicotinic Acetylcholine Receptors Study Computational Drug Discovery Methods

Affiliations

VIB-KU Leuven Center for Cancer Biology2014–2014

Centre for Human Drug Research2010–2010

Institute of Medicinal Plant Development2011–2011

Vrije Universiteit Amsterdam2009–2015

Top Works

Transforming fragments into candidates: small becomes big in medicinal chemistry

Gerdien E. de Kloe,David Bailey,et al.

2009178 citations

Ion channel regulation and function

Chemical Synthesis and Analysis

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

Mariano Stornaiuolo,Gerdien E. de Kloe,et al.

201369 citations

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays

Ferry Heus,Martin Giera,et al.

201039 citations

Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine-Binding Protein

Matthis Geitmann,Kim Retra,et al.

201037 citations

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands

Gerdien E. de Kloe,Kim Retra,et al.

201036 citations

Online Fluorescence Enhancement Assay for the Acetylcholine Binding Protein with Parallel Mass Spectrometric Identification

Jeroen Kool,Gerdien E. de Kloe,et al.

201035 citations

Fragment library design: efficiently hunting drugs in chemical space

Susan M. Boyd,Gerdien E. de Kloe

201033 citations

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A

Mark H.P. Verheij,Chris de Graaf,et al.

201132 citations

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics

Chris de Graaf,Henry F. Vischer,et al.

201231 citations