Researchclopedia

Research Researchers Institutions Topics Submit About

Command Palette

Search for a command to run...

Researchclopedia

Research Researchers Institutions About

© 2026 Researchclopedia. Powered by OpenAlex under CC0 license.

James B. Koprich | Researchclopedia

Back to researchers

James B. Koprich

University Health Network ORCID

86

Works

4,162

Citations

35

h-index

54

i10-index

Research Topics

Parkinson's Disease Mechanisms and Treatments Neurological disorders and treatments Nerve injury and regeneration

Affiliations

Rush University Medical Center2003–2011

University Health Network2010–2025

Harvard University2007–2010

Central Michigan University2004–2004

Fudan University2017–2024

Top Works

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV α-Synucleinopathy

Chee Yeun Chung,James B. Koprich,et al.

2009382 citations

Neuroscience and Neuropharmacology Research

Autism Spectrum Disorder Research

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

James B. Koprich,Casper Reske-Nielsen,et al.

2008345 citations

The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease

Philippe Huot,Tom H. Johnston,et al.

2013328 citations

Animal models of α-synucleinopathy for Parkinson disease drug development

James B. Koprich,Lorraine V. Kalia,et al.

2017230 citations

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

Chi Wang Ip,Laura-Christin Klaus,et al.

2017170 citations

α-Synuclein-Based Animal Models of Parkinson's Disease: Challenges and Opportunities in a New Era

Naomi P. Visanji,Jonathan M. Brotchie,et al.

2016162 citations

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease

James B. Koprich,Tom H. Johnston,et al.

2010147 citations

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Chris McKinnon,Mitchell L. de Snoo,et al.

2020135 citations

Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease

Qing He,James B. Koprich,et al.

2015124 citations