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Didier Merciris | Researchclopedia

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Didier Merciris

Galapagos (France)

24

Works

278

Citations

8

h-index

8

i10-index

Research Topics

Osteoarthritis Treatment and Mechanisms Protease and Inhibitor Mechanisms Cell Adhesion Molecules Research

Affiliations

Centre National de la Recherche Scientifique2003–2003

Inserm2006–2009

Délégation Paris 72009–2009

Université Paris-Est Créteil2003–2003

Université Paris Cité2003–2009

Top Works

Discovery of 9-Cyclopropylethynyl-2-((<i>S</i>)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-<i>a</i>]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial

Frédéric Labéguère,Sonia Dupont,et al.

202043 citations

Bone Metabolism and Diseases

Bone health and treatments

Heparin‐like dextran derivatives as well as glycosaminoglycans inhibit the enzymatic activity of human cathepsin G

Dominique Ledoux,Didier Merciris,et al.

200343 citations

Overexpression of the Transcriptional Factor Runx2 in Osteoblasts Abolishes the Anabolic Effect of Parathyroid Hormone in Vivo

Didier Merciris,Caroline Marty,et al.

200736 citations

Bone loss induced by Runx2 Over‐expression in mice is blunted by osteoblastic over‐expression of TIMP‐1

Corinne Schiltz,Christophe Prouillet,et al.

200927 citations

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5

P. Clément-Lacroix,Christopher B. Little,et al.

202125 citations

Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization

Roland Blanqué,L. Lepescheux,et al.

201424 citations

Over-expression of TIMP-1 in osteoblasts increases the anabolic response to PTH

Didier Merciris,Corinne Schiltz,et al.

200623 citations

Discovery of Clinical Candidate GLPG3970: A Potent and Selective Dual SIK2/SIK3 Inhibitor for the Treatment of Autoimmune and Inflammatory Diseases

Christophe Peixoto,Agnès Joncour,et al.

202421 citations

Early detection of osteoarthritis in the rat with an antibody specific to type II collagen modified by reactive oxygen species

Anne Gigout,Donata Harazin,et al.

20218 citations