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Megan M. Simonds | Researchclopedia

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Megan M. Simonds

Nemours Children's Health System ORCID

15

Works

138

Citations

6

h-index

5

i10-index

Research Topics

Autoimmune and Inflammatory Disorders Research Rheumatoid Arthritis Research and Therapies Bone Metabolism and Diseases

Affiliations

DuPont (United States)2014–2023

Alfred I. duPont Hospital for Children2020–2021

Wilmington University2014–2014

Community Health Systems - Dupont Hospital2020–2020

Nemours Children's Health System2014–2026

Top Works

The Role of Transforming Growth Factor β Signaling in Fibroblast‐like Synoviocytes From Patients With Oligoarticular Juvenile Idiopathic Arthritis: Dysregulation of Transforming Growth Factor β Signaling, Including Overexpression of Bone Morphogenetic Protein 4, May Lead to a Chondrocyte Phenotype and May Contribute to Bony Hypertrophy

AnneMarie C. Brescia,Megan M. Simonds,et al.

201356 citations

Immune Cell Function and Interaction

Inflammasome and immune disorders

Secretion of pro‐inflammatory cytokines and chemokines and loss of regulatory signals by fibroblast‐like synoviocytes in juvenile idiopathic arthritis

AnneMarie C. Brescia,Megan M. Simonds,et al.

201627 citations

The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes

Megan M. Simonds,Amanda R. Schlefman,et al.

202115 citations

Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype

Megan M. Simonds,Kathleen E. Sullivan,et al.

202214 citations

CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment

Lina Al‐Jaberi,Megan M. Simonds,et al.

202210 citations

Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation

Megan M. Simonds,Amanda R. Schlefman,et al.

20209 citations

Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable

AnneMarie C. Brescia,Megan M. Simonds,et al.

20183 citations

Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis

Megan M. Simonds,Samuel T. Freer,et al.

20232 citations

Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis

Megan M. Simonds,Samuel T. Freer,et al.

20242 citations