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Emmanouil Metzakopian | Researchclopedia

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Emmanouil Metzakopian

Babraham Institute ORCID

69

Works

3,355

Citations

24

h-index

34

i10-index

Research Topics

CRISPR and Genetic Engineering Autophagy in Disease and Therapy Nuclear Receptors and Signaling

Affiliations

Babraham Institute2023–2025

University of Cambridge2018–2024

Wellcome Sanger Institute2014–2019

Babraham Bioscience Technologies (United Kingdom)2024–2024

UK Dementia Research Institute2018–2025

Top Works

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

Konstantinos Tzelepis,Hiroko Koike-Yusa,et al.

2016817 citations

Single-cell and spatial transcriptomics

Genetics and Neurodevelopmental Disorders

Predicting the mutations generated by repair of Cas9-induced double-strand breaks

Felicity Allen,Luca Crepaldi,et al.

2018522 citations

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

Gabriel Balmus,Domenic Pilger,et al.

2019180 citations

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Malgorzata Gozdecka,Eshwar Meduri,et al.

2018166 citations

Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development

Wei Lin,Emmanouil Metzakopian,et al.

2009156 citations

Single-Cell Transcriptomics of Parkinson’s Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses

Hugo J. R. Fernandes,Nikolaos Patikas,et al.

2020141 citations

ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms

Emma Wilson,Emmanouil Metzakopian

2020136 citations

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing

Farah H. Siddiqi,Fiona M. Menzies,et al.

2019129 citations

Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution

Araks Martirosyan,Rizwan Ansari,et al.

202499 citations