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Hinrich Abken | Researchclopedia

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Hinrich Abken

University Hospital Regensburg ORCID

354

Works

13,041

Citations

64

h-index

185

i10-index

Research Topics

CAR-T cell therapy research Immune Cell Function and Interaction Immunotherapy and Immune Responses

Affiliations

Roche (Switzerland)2014–2014

University of Bonn1990–1999

University of Cape Town2012–2012

University of Cologne1994–2021

Center for Integrated Protein Science Munich2014–2014

Top Works

TRUCKs: the fourth generation of CARs

Markus Chmielewski,Hinrich Abken

2015689 citations

Virus-based gene therapy research

Viral Infectious Diseases and Gene Expression in Insects

IL-12 Release by Engineered T Cells Expressing Chimeric Antigen Receptors Can Effectively Muster an Antigen-Independent Macrophage Response on Tumor Cells That Have Shut Down Tumor Antigen Expression

Markus Chmielewski,Caroline Kopecky,et al.

2011530 citations

CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

Markus Chmielewski,Hinrich Abken

2017406 citations

Of <scp>CAR</scp>s and <scp>TRUCK</scp>s: chimeric antigen receptor (<scp>CAR</scp>) T cells engineered with an inducible cytokine to modulate the tumor stroma

Markus Chmielewski,Andreas Hombach,et al.

2013344 citations

Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule

Andreas Hombach,Anja Wieczarkowiecz,et al.

2001291 citations

T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity

Markus Chmielewski,Andreas Hombach,et al.

2004261 citations

Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

Barbara Savoldo,Cliona M. Rooney,et al.

2007235 citations

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response

Andreas Hombach,Andreas Hombach,et al.

2010226 citations

T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

K. Krebs,Nina Böttinger,et al.

2013218 citations