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Matthew L. Crawley | Researchclopedia

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Matthew L. Crawley

Merck & Co., Inc., Rahway, NJ, USA (United States)

49

Works

3,720

Citations

16

h-index

17

i10-index

Research Topics

Asymmetric Synthesis and Catalysis Asymmetric Hydrogenation and Catalysis Synthetic Organic Chemistry Methods

Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)2013–2013

Main Line Health2011–2012

Lafayette College1998–1998

Williams College2003–2004

BASF (United States)2001–2001

Top Works

Asymmetric Transition-Metal-Catalyzed Allylic Alkylations: Applications in Total Synthesis

Barry M. Trost,Matthew L. Crawley

20032,796 citations

Chemical Synthesis and Analysis

Protein Tyrosine Phosphatases

4-Aryloxybutenolides As “Chiral Aldehyde” Equivalents: An Efficient Enantioselective Synthesis of (+)-Brefeldin A

Barry M. Trost,Matthew L. Crawley

2002102 citations

Structure-Based Design and Discovery of Protein Tyrosine Phosphatase Inhibitors Incorporating Novel Isothiazolidinone Heterocyclic Phosphotyrosine Mimetics

Andrew P. Combs,Eddy W. Yue,et al.

2005101 citations

Potent Benzimidazole Sulfonamide Protein Tyrosine Phosphatase 1B Inhibitors Containing the Heterocyclic ( <i>S</i> )-Isothiazolidinone Phosphotyrosine Mimetic

Andrew P. Combs,Wenyu Zhu,et al.

200685 citations

α-Acetoxysulfones as “Chiral Aldehyde” Equivalents

Barry M. Trost,Matthew L. Crawley,et al.

200076 citations

Regioselective Synthesis of Substituted Pyrroles: Efficient Palladium-Catalyzed Cyclization of Internal Alkynes and 2-Amino-3-iodoacrylate Derivatives

Matthew L. Crawley,Igor Goljer,et al.

200673 citations

A “Chiral Aldehyde” Equivalent as a Building Block Towards Biologically Active Targets

Barry M. Trost,Matthew L. Crawley

200472 citations

Enantioselective Allylic Substitutions in Natural Product Synthesis

Barry M. Trost,Matthew L. Crawley

201167 citations

Structural Insights into the Design of Nonpeptidic Isothiazolidinone-containing Inhibitors of Protein-tyrosine Phosphatase 1B

J. Paul,Lucie Gonneville,et al.

200661 citations