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Gregory R. Hoffman | Researchclopedia

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Gregory R. Hoffman

Novartis (Switzerland)

57

Works

6,930

Citations

29

h-index

33

i10-index

Research Topics

CRISPR and Genetic Engineering Protein Kinase Regulation and GTPase Signaling Epigenetics and DNA Methylation

Affiliations

Mott MacDonald (United Kingdom)1986–1986

Novartis (Switzerland)2016–2025

Harvard University2007–2014

Cornell University1998–2008

University of Michigan–Ann Arbor2016–2016

Top Works

p53 inhibits CRISPR–Cas9 engineering in human pluripotent stem cells

Robert J. Ihry,Kathleen A. Worringer,et al.

2018994 citations

Pluripotent Stem Cells Research

Cellular transport and secretion

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

Yonghao Yu,Sang-Oh Yoon,et al.

2011870 citations

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

E. Robert McDonald,Antoine de Weck,et al.

2017693 citations

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis,E. Robert McDonald,et al.

2016555 citations

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks

Megan van Overbeek,Daniel Capurso,et al.

2016500 citations

Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI

Gregory R. Hoffman,Nicolas Nassar,et al.

2000491 citations

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

Gregory R. Hoffman,Rami Rahal,et al.

2014409 citations

Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

Christina H. Eng,Zuncai Wang,et al.

2015221 citations

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Sang Gyun Kim,Gregory R. Hoffman,et al.

2012211 citations