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Laura R. La Bonte | Researchclopedia

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Laura R. La Bonte

Novartis (United States)

32

Works

1,378

Citations

13

h-index

13

i10-index

Research Topics

Complement system in diseases Adenosine and Purinergic Signaling Platelet Disorders and Treatments

Affiliations

Brigham and Women's Hospital2010–2014

Foundation for Biomedical Research2017–2017

Médecins Sans Frontières2006–2006

Harvard University2010–2014

University of Arizona2007–2011

Top Works

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen,Matthew J. LaMarche,et al.

2016910 citations

Blood Coagulation and Thrombosis Mechanisms

Cardiac Ischemia and Reperfusion

Mannose-Binding Lectin-Associated Serine Protease-1 Is a Significant Contributor to Coagulation in a Murine Model of Occlusive Thrombosis

Laura R. La Bonte,Vasile I. Pavlov,et al.

201190 citations

Glucagon-like Peptide-1 (GLP-1), Immediately Prior to Reperfusion, Decreases Neutrophil Activation and Reduces Myocardial Infarct Size in Rodents

Betsy B. Dokken,Laura R. La Bonte,et al.

201173 citations

Complement inhibition reduces injury in the type 2 diabetic heart following ischemia and reperfusion

Laura R. La Bonte,Grace Davis‐Gorman,et al.

200840 citations

Design and Discovery of <i>N</i>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Savithri Ramurthy,Benjamin R. Taft,et al.

201938 citations

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition <i>in Vivo</i>

Edwige Lorthiois,Karen Anderson,et al.

201735 citations

The Partec CyFlow Counter® could provide an option for CD4+ T-cell monitoring in the context of scaling-up antiretroviral treatment at the district level in Malawi

M. Fryland,Pascale Chaillet,et al.

200634 citations

Human Mannose-Binding Lectin Inhibitor Prevents Myocardial Injury and Arterial Thrombogenesis in a Novel Animal Model

Vasile I. Pavlov,Ying Siow Tan,et al.

201431 citations

Absence of Mannose-Binding Lectin Prevents Hyperglycemic Cardiovascular Complications

Vasile I. Pavlov,Laura R. La Bonte,et al.

201129 citations