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Eric L. Wise | Researchclopedia

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Eric L. Wise

University of Michigan–Ann Arbor

23

Works

816

Citations

14

h-index

15

i10-index

Research Topics

Enzyme Structure and Function Genetic and Kidney Cyst Diseases Porphyrin Metabolism and Disorders

Affiliations

University of Wisconsin–Madison2002–2005

University of Illinois Urbana-Champaign2002–2005

University of California, San Francisco2002–2002

Pfizer (United States)2001–2001

University of Michigan–Ann Arbor2007–2015

Top Works

A Systematic Approach to Mapping Recessive Disease Genes in Individuals from Outbred Populations

Friedhelm Hildebrandt,Saskia F. Heeringa,et al.

2009162 citations

Amino Acid Enzymes and Metabolism

Biochemical and Molecular Research

Hypomorphic mutations in meckelin (<i>MKS3/TMEM67</i>) cause nephronophthisis with liver fibrosis (NPHP11)

Edgar A. Otto,Kálmán Tory,et al.

2009128 citations

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy

John F. O’Toole,Yangjian Liu,et al.

2010118 citations

Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing

Edgar A. Otto,Juliana Helou,et al.

200780 citations

4-Hydroxy-5,6-dihydropyrones as Inhibitors of HIV Protease: The Effect of Heterocyclic Substituents at C-6 on Antiviral Potency and Pharmacokinetic Parameters

Susan E. Hagen,John M. Domagala,et al.

200159 citations

Homologous (β/α) <sub>8</sub> -Barrel Enzymes That Catalyze Unrelated Reactions: Orotidine 5‘-Monophosphate Decarboxylase and 3-Keto- <scp>l</scp> -Gulonate 6-Phosphate Decarboxylase <sup>,</sup>

Eric L. Wise,Wen Shan Yew,et al.

200257 citations

Evolution of Enzymatic Activities in the Orotidine 5‘-Monophosphate Decarboxylase Suprafamily: Enhancing the Promiscuous <scp>d</scp> - <i>arabino</i> -Hex-3-ulose 6-Phosphate Synthase Reaction Catalyzed by 3-Keto- <scp>l</scp> -gulonate 6-Phosphate Decarboxylase

Wen Shan Yew,Julie Akana,et al.

200542 citations

Understanding the Importance of Protein Structure to Nature's Routes for Divergent Evolution in TIM Barrel Enzymes

Eric L. Wise,Ivan Rayment

200438 citations

Evolution of Enzymatic Activities in the Orotidine 5‘-Monophosphate Decarboxylase Suprafamily: Structural Basis for Catalytic Promiscuity in Wild-Type and Designed Mutants of 3-Keto-<scp>l</scp>-gulonate 6-Phosphate Decarboxylase

Eric L. Wise,Wen Shan Yew,et al.

200530 citations