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Daniel P. Walker | Researchclopedia

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Daniel P. Walker

Bayer (United States)

68

Works

2,178

Citations

22

h-index

41

i10-index

Research Topics

Pancreatic function and diabetes Cannabis and Cannabinoid Research Drug Transport and Resistance Mechanisms

Affiliations

Synopsys (Switzerland)2013–2013

Bayer (United States)2019–2024

Pfizer (United States)2006–2018

University of Washington2011–2011

Curtin University2020–2023

Top Works

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

Antonia F. Stepan,Daniel P. Walker,et al.

2011689 citations

Nicotinic Acetylcholine Receptors Study

Receptor Mechanisms and Signaling

Discovery of<i>N</i>-[(3<i>R</i>)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-<i>c</i>]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia: Synthesis and Structure−Activity Relationship

Donn G. Wishka,Daniel P. Walker,et al.

2006189 citations

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

Seungil Han,Anil Mistry,et al.

2009107 citations

Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

Ken Blount,Cynthia M. Megyola,et al.

2015100 citations

Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists

Daniel P. Walker,Donn G. Wishka,et al.

200694 citations

Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity

Daniel P. Walker,Michael P. Zawistoski,et al.

200986 citations

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo activity

Brad A. Acker,E. Jon Jacobsen,et al.

200860 citations

Alginate-based drug oral targeting using bio-micro/nano encapsulation technologies

Susbin Raj Wagle,Božica Kovačević,et al.

202056 citations

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

Daniel P. Walker,F. Christopher Bi,et al.

200851 citations