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Liesbeth van Deemter | Researchclopedia

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Liesbeth van Deemter

34

Works

11,236

Citations

25

h-index

25

i10-index

Research Topics

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies PARP inhibition in cancer therapy

Affiliations

AstraZeneca (United Kingdom)2012–2012

St. Jude Children's Research Hospital2002–2002

Target (United States)2012–2012

Radboud University Nijmegen2002–2002

Slotervaartziekenhuis2002–2002

Top Works

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel,Jasper Smit,et al.

19942,272 citations

Pediatric Hepatobiliary Diseases and Treatments

Epilepsy research and treatment

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit,Alfred H. Schinkel,et al.

19931,460 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel,Els Wagenaar,et al.

19961,265 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel,Els Wagenaar,et al.

19951,112 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel,Ulrich Mayer,et al.

1997938 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

Raymond Evers,Marcel Kool,et al.

1998615 citations

Loss of 53BP1 Causes PARP Inhibitor Resistance in <i>Brca1</i> -Mutated Mouse Mammary Tumors

Janneke E. Jaspers,Ariena Kersbergen,et al.

2012511 citations

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

Jan Wijnholds,Carla A.A.M. Mol,et al.

2000472 citations

Characterization of the Transport of Nucleoside Analog Drugs by the Human Multidrug Resistance Proteins MRP4 and MRP5

Glen Reid,Peter R. Wielinga,et al.

2003365 citations