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Alfred H. Schinkel | Researchclopedia

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Alfred H. Schinkel

Oncode Institute ORCID

432

Works

38,464

Citations

95

h-index

254

i10-index

Research Topics

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Pharmacogenetics and Drug Metabolism

Affiliations

Kanazawa University2014–2014

Merck & Co., Inc., Rahway, NJ, USA (United States)2014–2014

St. Jude Children's Research Hospital2000–2008

Inserm1998–1998

Bristol-Myers Squibb (Germany)2014–2014

Top Works

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel,Jasper Smit,et al.

19942,272 citations

Cancer therapeutics and mechanisms

Acute Lymphoblastic Leukemia research

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

Jasper Smit,Alfred H. Schinkel,et al.

19931,460 citations

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel,Johan W. Jonker

20031,359 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel,Els Wagenaar,et al.

19961,265 citations

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

Alfred H. Schinkel,Johan W. Jonker

20121,226 citations

Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.

Marc Maliepaard,George L. Scheffer,et al.

20011,128 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel,Els Wagenaar,et al.

19951,112 citations

P-Glycoprotein, a gatekeeper in the blood–brain barrier

Alfred H. Schinkel

1999952 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

Alfred H. Schinkel,Ulrich Mayer,et al.

1997938 citations