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Martina Fitzek | Researchclopedia

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Martina Fitzek

Karolinska Institutet

38

Works

718

Citations

11

h-index

12

i10-index

Research Topics

PI3K/AKT/mTOR signaling in cancer Chronic Lymphocytic Leukemia Research Protein Kinase Regulation and GTPase Signaling

Affiliations

AstraZeneca (United Kingdom)2008–2024

Karolinska Institutet2025–2025

Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien1988–1988

Top Works

Vectors for efficient expression in mammalian fibroblastoid, myeloid and lymphoid cells via transfection or infection

Petra Artelt,Christine Morelle,et al.

1988169 citations

Cancer, Lipids, and Metabolism

Biochemical and Molecular Research

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

Grace Q. Gong,Benoît Bilanges,et al.

2023141 citations

Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel

Urs J. Hancox,Sabina Cosulich,et al.

201499 citations

Discovery of (<i>R</i>)-8-(1-(3,5-Difluorophenylamino)ethyl)-<i>N</i>,<i>N</i>-dimethyl-2-morpholino-4-oxo-4<i>H</i>-chromene-6-carboxamide (AZD8186): A Potent and Selective Inhibitor of PI3Kβ and PI3Kδ for the Treatment of PTEN-Deficient Cancers

Bernard Barlaam,Sabina Cosulich,et al.

201486 citations

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

Richard Ducray,Iain Simpson,et al.

201148 citations

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers

Bernard Barlaam,Sabina Cosulich,et al.

201535 citations

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Bernard Barlaam,Sabina Cosulich,et al.

201419 citations

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

Hugo Brito,Vanda Marques,et al.

202018 citations

A small molecule inhibitor of HER3: a proof-of-concept study

Audrey Colomba,Martina Fitzek,et al.

202013 citations