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Ophir Shalem | Researchclopedia

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Ophir Shalem

Children's Hospital of Philadelphia ORCID

142

Works

26,564

Citations

29

h-index

49

i10-index

Research Topics

CRISPR and Genetic Engineering CAR-T cell therapy research Pancreatic and Hepatic Oncology Research

Affiliations

Broad Institute2013–2017

Children's Hospital of Philadelphia2017–2025

Howard Hughes Medical Institute2019–2019

McGovern Institute for Brain Research2013–2017

California Institute for Regenerative Medicine2019–2019

Top Works

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem,Neville E. Sanjana,et al.

20135,447 citations

RNA and protein synthesis mechanisms

Ferroptosis and cancer prognosis

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana,Ophir Shalem,et al.

20145,437 citations

DNA targeting specificity of RNA-guided Cas9 nucleases

Patrick D. Hsu,David A. Scott,et al.

20134,834 citations

In vivo genome editing using Staphylococcus aureus Cas9

F. Ann Ran,Le Cong,et al.

20152,686 citations

High-throughput functional genomics using CRISPR–Cas9

Ophir Shalem,Neville E. Sanjana,et al.

20151,232 citations

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Sidi Chen,Neville E. Sanjana,et al.

2015923 citations

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Matthew C. Canver,Elenoe C. Smith,et al.

2015898 citations

Identification of essential genes for cancer immunotherapy

Shashank J. Patel,Neville E. Sanjana,et al.

2017885 citations

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Anna‐Leigh Brown,Oscar G. Wilkins,et al.

2022486 citations