Researchclopedia

Research Researchers Institutions Topics Submit About

Command Palette

Search for a command to run...

Researchclopedia

Research Researchers Institutions About

© 2026 Researchclopedia. Powered by OpenAlex under CC0 license.

Karen O’Rourke | Researchclopedia

Back to researchers

Karen O’Rourke

Fondation pour la Recherche Stratégique

56

Works

28,986

Citations

42

h-index

47

i10-index

Research Topics

Cell death mechanisms and regulation Ubiquitin and proteasome pathways Angiogenesis and VEGF in Cancer

Affiliations

California Institute of Technology2004–2004

University of North Texas1995–1995

Howard Hughes Medical Institute2004–2004

University of Wisconsin–Madison1994–1994

University of California, Los Angeles2007–2007

Top Works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki,Irma B. Stowe,et al.

20153,569 citations

Protease and Inhibitor Mechanisms

NF-κB Signaling Pathways

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio,Arul M. Chinnaiyan,et al.

19963,049 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

Sanjeev Mariathasan,David S. Weiss,et al.

20063,013 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

Arul M. Chinnaiyan,Karen O’Rourke,et al.

19952,419 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Muneesh Tewari,Long T. Quan,et al.

19952,390 citations

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling

Ingrid E. Wertz,Karen O’Rourke,et al.

20041,818 citations

The Receptor for the Cytotoxic Ligand TRAIL

Guohua Pan,Karen O’Rourke,et al.

19971,771 citations

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz,Saritha Kusam,et al.

2011809 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

Arul M. Chinnaiyan,Clifford G. Tepper,et al.

1996773 citations