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Jie Shen | Researchclopedia

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Jie Shen

Peking University ORCID

159

Works

19,455

Citations

55

h-index

102

i10-index

Research Topics

Alzheimer's disease research and treatments Parkinson's Disease Mechanisms and Treatments Nuclear Receptors and Signaling

Affiliations

Boston University2013–2013

Brigham and Women's Hospital1998–2024

Harvard University1999–2024

Central South University2020–2020

Eli Lilly (United States)2019–2019

Top Works

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra,Seok Min Jin,et al.

20102,862 citations

Neuroscience and Neuropharmacology Research

Cholinesterase and Neurodegenerative Diseases

α-Synuclein is phosphorylated in synucleinopathy lesions

Hideo Fujiwara,Masato Hasegawa,et al.

20022,154 citations

Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice

James Palacino,Dijana Šagi,et al.

2004996 citations

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Matthew S. Goldberg,Sheila M. Fleming,et al.

2003910 citations

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Clément Gautier,Tohru Kitada,et al.

2008688 citations

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Matthew S. Goldberg,Antonio Pisani,et al.

2005543 citations

Impaired dopamine release and synaptic plasticity in the striatum of <i>PINK1</i> -deficient mice

Tohru Kitada,Antonio Pisani,et al.

2007537 citations

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

Youren Tong,Hiroo Yamaguchi,et al.

2010505 citations

The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism

Jie Shen,Raymond J. Kelleher

2006489 citations